Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20592862&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Role of histone methylation and demethylation in adipogenesis and obesity Okamura M; Inagaki T; Tanaka T; Sakai JOrganogenesis 2010[Jan]; 6 (1): 24-32Adipocyte differentiation is a complex developmental process that involves the coordinated interplay of numerous transcription factors. PPARgamma has emerged as a master regulator of adipogenesis and recent global target gene analysis demonstrated that PPARgamma targets many genes encoding chromatin modification enzymes as well as genes of lipid metabolism and storage. Among such modification enzymes are histone lysine methyltransferases, which play important roles in transcriptional regulation. Histone methyltransferases are involved in PPARgamma gene expression and subsequent adipogenesis. In addition, recent studies revealed that demethylation of histone H3 at lys9 is associated with resistance to obesity. We here review the role of histone methylation and demethylation in adipogenesis, metabolism and obesity.|*DNA Methylation[MESH]|Adipogenesis/genetics/*physiology[MESH]|Animals[MESH]|Histone-Lysine N-Methyltransferase/metabolism[MESH]|Histones/genetics/*metabolism[MESH]|Humans[MESH]|Obesity/*genetics/*metabolism/pathology[MESH]|PPAR gamma/biosynthesis/genetics[MESH] |
