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lüll TMSG-1 and its roles in tumor biology Xu XY; Pei F; You JFChin J Cancer 2010[Jul]; 29 (7): 697-702TMSG-1 is a newly discovered tumor metastasis suppressor gene, which plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells. The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H+-ATPase and ceramide, but the underlying mechanism remains unknown. Studies on TMSG-1 are limited worldwide, and only a research group in Shanghai and our group have recently studied on it. As a new research field, the function of TMSG-1 remains to be explored. This review discusses the discovery of TMSG-1, structure of its encoded protein, its roles and possible mechanism in inhibiting tumor invasion and metastasis.|*Neoplasms/metabolism/pathology[MESH]|Animals[MESH]|Apoptosis/drug effects[MESH]|Cell Cycle/drug effects[MESH]|Ceramides/chemical synthesis/*pharmacology[MESH]|Enzyme Activation[MESH]|Humans[MESH]|Membrane Proteins/*metabolism/physiology[MESH]|Neoplasm Invasiveness[MESH]|Neoplasm Metastasis[MESH]|Phosphorylation[MESH]|Sphingosine N-Acyltransferase/*metabolism/physiology[MESH]|Tumor Suppressor Proteins/*metabolism/physiology[MESH]|Vacuolar Proton-Translocating ATPases/*metabolism[MESH] |