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Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1 s multifunctional regulatory roles Chaudhury A; Chander P; Howe PHRNA 2010[Aug]; 16 (8): 1449-62Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a family of RNA-binding proteins. The complexity and diversity associated with the hnRNPs render them multifunctional, involved not only in processing heterogeneous nuclear RNAs (hnRNAs) into mature mRNAs, but also acting as trans-factors in regulating gene expression. Heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1), a subgroup of hnRNPs, is a KH-triple repeat containing RNA-binding protein. It is encoded by an intronless gene arising from hnRNP E2 through a retrotransposition event. hnRNP E1 is ubiquitously expressed and functions in regulating major steps of gene expression, including pre-mRNA processing, mRNA stability, and translation. Given its wide-ranging functions in the nucleus and cytoplasm and interaction with multiple proteins, we propose a post-transcriptional regulon model that explains hnRNP E1's widespread functional diversity.|Cell Nucleus/metabolism[MESH]|Cytoplasm/metabolism[MESH]|Heterogeneous-Nuclear Ribonucleoproteins/*metabolism[MESH]|Humans[MESH]|RNA Precursors/metabolism[MESH]|RNA, Heterogeneous Nuclear/*metabolism[MESH]|RNA, Messenger/metabolism[MESH]|RNA-Binding Proteins/*metabolism[MESH] |
