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lüll Challenges in the classification of atrial fibrillation Lubitz SA; Benjamin EJ; Ruskin JN; Fuster V; Ellinor PTNat Rev Cardiol 2010[Aug]; 7 (8): 451-60The incidence and prevalence of atrial fibrillation (AF) are increasing worldwide. AF is of public health importance because it accounts for substantial morbidity, mortality, and health-care costs. AF may be transient initially, but many patients have progressive disease marked by increasing frequency and duration of episodes. Various classification schemes for AF have been proposed, although current guidelines are based on temporal rhythm-based patterns. We discuss existing schemes for the classification of AF, focusing on the advantages and limitations of the pattern-based scheme, in the context of new knowledge about AF pathophysiology, AF patterns, and clinical outcomes. Furthermore, we address gaps in knowledge that present opportunities to re-examine the current pattern-based classification of AF. A future classification scheme should ideally combine elements such as the risk of stroke, an assessment of symptoms, and the degree of impairment of the atrial substrate.|*Atrial Function[MESH]|*Heart Rate[MESH]|*Terminology as Topic[MESH]|Atrial Fibrillation/*classification/diagnosis/physiopathology/therapy[MESH]|Disease Progression[MESH]|Electrocardiography[MESH]|Heart Conduction System/*physiopathology[MESH]|Humans[MESH]|Predictive Value of Tests[MESH]|Prognosis[MESH]|Severity of Illness Index[MESH] |