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Structural insights into G-quadruplexes: towards new anticancer drugs Yang D; Okamoto KFuture Med Chem 2010[Apr]; 2 (4): 619-46DNA G-quadruplexes are DNA secondary structures formed in specific G-rich sequences. DNA sequences that can form G-quadruplexes have been found in regions with biological significance, such as human telomeres and oncogene-promoter regions. DNA G-quadruplexes have recently emerged as a new class of novel molecular targets for anticancer drugs. Recent progress on structural studies of the biologically relevant G-quadruplexes formed in human telomeres and in the promoter regions of human oncogenes will be discussed, as well as recent advances in the design and development of G-quadruplex-interactive drugs. DNA G-quadruplexes can readily form in solution under physiological conditions and are globularly folded nucleic acid structures. The molecular structures of intramolecular G-quadruplexes appear to differ from one another and, therefore, in principle may be differentially regulated and targeted by different proteins and drugs.|*G-Quadruplexes[MESH]|Animals[MESH]|Antineoplastic Agents/*chemistry/*therapeutic use[MESH]|Base Sequence[MESH]|DNA-Binding Proteins/chemistry/metabolism[MESH]|DNA/*chemistry/genetics[MESH]|Genes, myc[MESH]|Humans[MESH]|Hydrogen Bonding[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH]|Molecular Structure[MESH]|Neoplasms/*drug therapy/*genetics[MESH]|Oncogenes[MESH]|Polymorphism, Genetic[MESH]|Promoter Regions, Genetic/genetics[MESH]|Telomere/genetics[MESH] |
