Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Mitochondrial aldehyde dehydrogenase and cardiac diseases Chen CH; Sun L; Mochly-Rosen DCardiovasc Res 2010[Oct]; 88 (1): 51-7Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes that cause cell damage and contribute to cardiac diseases. Aldehyde dehydrogenases (ALDHs) are important enzymes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. The review will discuss evidence indicating a role for a specific ALDH enzyme, the mitochondrial ALDH2, in combating oxidative stress by reducing the cellular 'aldehydic load'. Epidemiological studies in humans carrying an inactive ALDH2, genetic models in mice with altered ALDH2 levels, and small molecule activators of ALDH2 all highlight the role of ALDH2 in cardioprotection and suggest a promising new direction in cardiovascular research and the development of new treatments for cardiovascular diseases.|*Oxidative Stress[MESH]|Aldehyde Dehydrogenase, Mitochondrial[MESH]|Aldehyde Dehydrogenase/genetics/*metabolism[MESH]|Aldehydes/*metabolism[MESH]|Animals[MESH]|Enzyme Activation[MESH]|Heart Diseases/*enzymology/genetics/therapy[MESH]|Humans[MESH]|Isoenzymes[MESH]|Mitochondria, Heart/*enzymology[MESH]|Myocardium/*enzymology[MESH]|Oxidation-Reduction[MESH] |