Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Cellular phenotype switching and microvesicles Quesenberry PJ; Aliotta JMAdv Drug Deliv Rev 2010[Sep]; 62 (12): 1141-8Cell phenotype alteration by cell-derived vesicles presents a new aspect for consideration of cell fate. Accumulating data indicates that vesicles from many cells interact with or enter different target cells from other tissues, altering their phenotype toward that of the cell releasing the vesicles. Cells may be changed by direct interactions, transfer of cell surface receptors or epigenetic reprogramming via transcriptional regulators. Induced epigenetic changes appear to be stable and result in significant functional effects. These data force a reconsideration of the cellular context in which transcription regulates the proliferative and differentiative fate of tissues and suggests a highly plastic cellular system, which might underlay a relatively stable tissue system. The capacity of marrow to convert to non-hematopoietic cells related to vesicle cross-communication may underlie the phenomena of stem cell plasticity. Additionally, vesicles have promise in the clinical arenas of disease biomarkers, tissue restoration and control of neoplastic cell growth.|*Cell Differentiation[MESH]|*Cell-Derived Microparticles/metabolism[MESH]|*Cytoplasmic Vesicles[MESH]|Bone Marrow Cells/physiology[MESH]|Cell Communication[MESH]|Cell Cycle[MESH]|Cell Fusion[MESH]|Epigenomics[MESH]|Exosomes/metabolism[MESH]|Gene Expression Regulation[MESH]|Hematopoietic Stem Cells/cytology/*physiology[MESH]|Humans[MESH]|Phenotype[MESH]|Stem Cells/*physiology[MESH] |