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Semaphorins and their receptors: novel features of neural guidance molecules Kumanogoh A; Kikutani HProc Jpn Acad Ser B Phys Biol Sci 2010[]; 86 (6): 611-20Semaphorins were originally identified as axon guidance cues involved in the development of the nervous system. In recent years, it is emerging that they also participate in various biological systems, including physiological and pathological processes. In this review, we primarily focus on our cumulative findings for the role of semaphorins and their receptors in the regulation of the immune system, while also summarizing recent progress in the context of cardiovascular system.|Animals[MESH]|Cardiovascular System/growth & development/metabolism[MESH]|Endothelial Cells/cytology/metabolism[MESH]|Humans[MESH]|Immune System/immunology/metabolism[MESH]|Nervous System/*metabolism[MESH]|Receptors, Cell Surface/*immunology/*metabolism[MESH]|Semaphorins/*immunology/*metabolism[MESH] |
