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Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment Seino S; Shibasaki T; Minami KProc Jpn Acad Ser B Phys Biol Sci 2010[]; 86 (6): 563-77Pancreatic beta-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the beta-cells and/or a decrease in the beta-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. Clarification of the mechanisms of insulin secretion and beta-cell fate provides a basis for the understanding of diabetes and its better treatment. In this review, we discuss cell signaling critical for the insulin secretory function based on our recent studies.|*Signal Transduction[MESH]|Animals[MESH]|Cyclic AMP/metabolism[MESH]|Diabetes Mellitus/metabolism/*pathology/*therapy[MESH]|Humans[MESH]|Insulin Secretion[MESH]|Insulin-Secreting Cells/metabolism/*pathology[MESH]|Insulin/metabolism[MESH]|Pancreas, Exocrine/pathology[MESH] |
