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  • Calcium signaling through CatSper channels in mammalian fertilization
  • Ren D; Xia J
  • Physiology (Bethesda) 2010[Jun]; 25 (3): 165-75
  • The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought.
  • |Animals[MESH]
  • |Calcium Channels/genetics/*physiology[MESH]
  • |Calcium Signaling/*physiology[MESH]
  • |Fertilization/*physiology[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Mice, Knockout[MESH]
  • |Models, Animal[MESH]
  • |Sperm Motility/physiology[MESH]





  • *{{pmid20551230}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=20551230 Calcium signaling through CatSper channels in mammalian fertilization ]</b> Physiology (Bethesda) 2010; 25(3) ; 165-75 Ren D; Xia J

        *20551230*

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    Physiology (Bethesda)

    165 3.25 2010