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l�ll The quest to understand heterotrimeric G protein signaling Tesmer JJNat Struct Mol Biol 2010[Jun]; 17 (6): 650-2Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein-coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs.|Animals[MESH]|Guanosine Triphosphate/metabolism[MESH]|Heterotrimeric GTP-Binding Proteins/chemistry/*metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Receptors, G-Protein-Coupled/chemistry/metabolism[MESH]|Rhodopsin/chemistry/metabolism[MESH]|Signal Transduction/*physiology[MESH] |