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Enhanced interrogation: emerging strategies for cell signaling inhibition Huang R; Martinez-Ferrando I; Cole PANat Struct Mol Biol 2010[Jun]; 17 (6): 646-9Here we summarize recent and developing chemical approaches for modulating signaling pathways. In particular, we discuss targeting mutant signaling proteins, disrupting protein-protein interactions in cellular signaling networks, designing bivalent inhibitors of signaling proteins and identifying allosteric regulators of signaling enzymes. Over the past decade, great progress in the harvesting of chemical tools for basic research and clinical medicine has been made, but many challenges remain, and examples of exciting future targets are highlighted.|Allosteric Regulation[MESH]|Animals[MESH]|Humans[MESH]|Models, Biological[MESH]|Mutant Proteins/antagonists & inhibitors/physiology[MESH]|Neoplasms/drug therapy/genetics/physiopathology[MESH]|Protein Interaction Domains and Motifs/drug effects[MESH]|Protein Sorting Signals/drug effects[MESH]|Signal Transduction/drug effects/*physiology[MESH] |
