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lüll The complement cascade as a mediator of tissue growth and regeneration Rutkowski MJ; Sughrue ME; Kane AJ; Ahn BJ; Fang S; Parsa ATInflamm Res 2010[Nov]; 59 (11): 897-905Recent evidence has demonstrated that the complement cascade is involved in a variety of physiologic and pathophysiologic processes in addition to its role as an immune effector. Research in a variety of organ systems has shown that complement proteins are direct participants in maintenance of cellular turnover, healing, proliferation and regeneration. As a physiologic housekeeper, complement proteins maintain tissue integrity in the absence of inflammation by disposing of cellular debris and waste, a process critical to the prevention of autoimmune disease. Developmentally, complement proteins influence pathways including hematopoietic stem cell engraftment, bone growth, and angiogenesis. They also provide a potent stimulus for cellular proliferation including regeneration of the limb and eye in animal models, and liver proliferation following injury. Here, we describe the complement cascade as a mediator of tissue growth and regeneration.|Animals[MESH]|Complement Activation[MESH]|Complement System Proteins/*immunology[MESH]|Humans[MESH]|Inflammation/*immunology[MESH]|Regeneration/*immunology[MESH]|Signal Transduction/immunology[MESH] |