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  • Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity
  • Mai J; Wang H; Yang XF
  • Front Biosci (Landmark Ed) 2010[Jun]; 15 (): 986-1006
  • T helper 17 cells (Th17) are a new CD4+ T helper subset that has been implicated in inflammatory and autoimmune diseases. Th17, along with CD4(+)CD25(high) Foxp3(+) regulatory T cells (Tregs) and other new T helper subsets, have expanded the Th1-Th2 paradigm. Although this new eight-subset paradigm significantly improved our understanding on the differentiation and regulation of CD4+ T helper subsets, many questions remain to be answered. Here we will briefly review the following issues: a) Old Th1-Th2 paradigm versus new multi-subset paradigm; b) Structural features of IL-17 family cytokines; c) Th17 cells; d) Effects of IL-17 on various cell types and tissues; e) IL-17 receptor and signaling pathways; f) Th17-mediated inflammations; and g) Protective mechanisms of IL-17 in infections. Lastly, we will examine the interactions of Th17 and Treg in autoimmune diseases and inflammation: Th17 cells interplay with Tregs. Regulation of autoimmunity and inflammation lies in the interplays of the different T helper subsets, therefore, better understanding of these subsets' interactions would greatly improve our approaches in developing therapy to combat inflammatory and autoimmune diseases.
  • |Animals[MESH]
  • |Autoimmune Diseases/immunology[MESH]
  • |Autoimmunity/*immunology[MESH]
  • |Cytokines/immunology/metabolism[MESH]
  • |Forkhead Transcription Factors/immunology/metabolism[MESH]
  • |Humans[MESH]
  • |Inflammation/*immunology[MESH]
  • |Interleukin-17/immunology/metabolism[MESH]
  • |T-Lymphocytes, Helper-Inducer/*immunology/metabolism[MESH]
  • |T-Lymphocytes, Regulatory/*immunology/metabolism[MESH]

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    *<b>[ Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity ]</b> Front Biosci (Landmark Ed) 2010; 15() ; 986-1006 Mai J; Wang H; Yang XF


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    Front Biosci (Landmark Ed)

    986 .15 2010