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lüll Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies Hirai S; Takahashi N; Goto T; Lin S; Uemura T; Yu R; Kawada TMediators Inflamm 2010[]; 2010 (ä): 367838Obesity is associated with a low-grade systemic chronic inflammatory state, characterized by the abnormal production of pro- and anti-inflammatory adipocytokines. It has been found that immune cells such as macrophages can infiltrate adipose tissue and are responsible for the majority of inflammatory cytokine production. Obesity-induced inflammation is considered a potential mechanism linking obesity to its related pathologies, such as insulin resistance, cardiovascular diseases, type-2 diabetes, and some immune disorders. Therefore, targeting obesity-related inflammatory components may be a useful strategy to prevent or ameliorate the development of such obesity-related diseases. It has been shown that several food components can modulate inflammatory responses in adipose tissue via various mechanisms, some of which are dependent on peroxisome proliferator-activated receptor gamma (PPARgamma), whereas others are independent on PPARgamma, by attenuating signals of nuclear factor-kappaB (NF-kappaB) and/or c-Jun amino-terminal kinase (JNK). In this review, we introduce the beneficial effects of anti-inflammatory phytochemicals that can help prevent obesity-induced inflammatory responses and pathologies.|*Functional Food[MESH]|*Inflammation/diet therapy/etiology/immunology[MESH]|*Obesity/complications/immunology/pathology[MESH]|Adipokines/immunology[MESH]|Adipose Tissue/immunology[MESH]|Animals[MESH]|Humans[MESH]|Insulin Resistance[MESH]|PPAR gamma/metabolism[MESH]|Plant Extracts/metabolism[MESH]|Signal Transduction[MESH] |