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lüll Primary systemic chemotherapy for inflammatory breast cancer Sinclair S; Swain SMCancer 2010[Jun]; 116 (11 Suppl): 2821-8The advent of multimodality therapy for patients with inflammatory breast cancer (IBC), consisting of neoadjuvant chemotherapy, particularly taxanes, surgery, radiotherapy, and hormonal therapy, has improved survival. A pathologic complete response to neoadjuvant chemotherapy in locally advanced breast cancer and IBC improves outcomes, which suggests that obtaining a pathologic complete response to neoadjuvant chemotherapy has prognostic significance. The benefit of high-dose chemotherapy has shown encouraging results; however, this approach needs to be prospectively evaluated and to date remains experimental. Vascular endothelial growth factor, a promoter of angiogenesis, is highly expressed in IBC, making the angiogenesis pathway an attractive therapeutic target. A better understanding of the complex biology of IBC is needed for the development of additional targeted agents to further improve outcomes for patients with this aggressive form of breast cancer.|Antineoplastic Combined Chemotherapy Protocols/*therapeutic use[MESH]|Breast Neoplasms/*drug therapy/radiotherapy/surgery[MESH]|Chemotherapy, Adjuvant[MESH]|Female[MESH]|Humans[MESH]|Inflammation/therapy[MESH]|Neoadjuvant Therapy[MESH]|Prognosis[MESH]|Radiotherapy, Adjuvant[MESH]|Taxoids/therapeutic use[MESH] |