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  • Genetic variation in microRNA networks: the implications for cancer research
  • Ryan BM; Robles AI; Harris CC
  • Nat Rev Cancer 2010[Jun]; 10 (6): 389-402
  • Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future.
  • |*Gene Expression Regulation, Neoplastic[MESH]
  • |*Gene Regulatory Networks[MESH]
  • |*Polymorphism, Single Nucleotide[MESH]
  • |Alternative Splicing[MESH]
  • |Animals[MESH]
  • |Humans[MESH]
  • |MicroRNAs/chemistry/*genetics[MESH]
  • |Neoplasms/chemistry/*genetics[MESH]





  • *{{pmid20495573}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=20495573 Genetic variation in microRNA networks: the implications for cancer research ]</b> Nat Rev Cancer 2010; 10(6) ; 389-402 Ryan BM; Robles AI; Harris CC

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    Nat Rev Cancer

    389 6.10 2010