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Signal integration through blending, bolstering and bifurcating of intracellular information Pawson CT; Scott JDNat Struct Mol Biol 2010[Jun]; 17 (6): 653-8A cell's response to its environment is often determined by signaling through the actions of enzyme cascades. The ability to organize these enzymes into multiprotein complexes allows for a high degree of fidelity, efficiency and spatial precision in signaling responses.|Animals[MESH]|Enzymes/metabolism[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/metabolism[MESH]|Intracellular Space/metabolism[MESH]|Models, Biological[MESH]|Multienzyme Complexes/metabolism[MESH]|Signal Transduction/*physiology[MESH] |
