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Getting under the skin: the immunopathogenesis of Streptococcus pyogenes deep tissue infections Johansson L; Thulin P; Low DE; Norrby-Teglund AClin Infect Dis 2010[Jul]; 51 (1): 58-65Streptococcus pyogenes can cause a variety of diseases in immunocompetent individuals, from pharyngotonsillitis to life-threatening invasive diseases, such as streptococcal toxic shock syndrome, and rapidly progressing deep-tissue infections, such as necrotizing fasciitis. Necrotizing fasciitis is often seen in combination with streptococcal toxic shock syndrome, which further increases morbidity and mortality. We review here the host-pathogen interactions in the tissue milieu and discuss the use of intravenous immunoglobulin as potential adjunctive therapy in these life-threatening infections.|*Host-Pathogen Interactions[MESH]|Adjuvants, Immunologic/therapeutic use[MESH]|Humans[MESH]|Immunoglobulins, Intravenous/therapeutic use[MESH]|Skin Diseases, Bacterial/drug therapy/*microbiology[MESH]|Skin/microbiology[MESH]|Streptococcal Infections/drug therapy/*microbiology[MESH]|Streptococcus pyogenes/*physiology[MESH] |
