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Evidence-based non-skeletal actions of vitamin D Muszkat P; Camargo MB; Griz LH; Lazaretti-Castro MArq Bras Endocrinol Metabol 2010[Mar]; 54 (2): 110-7Vitamin D is a major regulator of mineral homeostasis through its action in the kidney, intestine, bone and parathyroid glands. On these tissues, its active form, calcitriol, acts by binding to a specific nuclear receptor that belongs to the steroid/thyroid hormone receptor family. This receptor, however, has also been identified in several additional human tissues. So, apart from its traditional actions related to calcium, vitamin D and its synthetic analogs are being increasingly recognized for their anti-proliferative, pro-differentiative and immunomodulatory activities. Low levels of vitamin D have been linked to many chronic diseases. Decreased muscle function and increased fall risk in elderly people; prostate, breast and colorectal cancers; diabetes mellitus; and other health problems have been associated to low circulating levels of 25-hydroxyvitamin D. This paper presents an overview of the available scientific evidence for the non-calcemic actions of vitamin D in humans.|*Dietary Supplements[MESH]|Calcium/*metabolism[MESH]|Humans[MESH]|Muscle, Skeletal/drug effects/physiology[MESH]|Vitamin D Deficiency/*prevention & control[MESH]|Vitamin D/*administration & dosage/physiology[MESH] |
