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The mouse retina as an angiogenesis model Stahl A; Connor KM; Sapieha P; Chen J; Dennison RJ; Krah NM; Seaward MR; Willett KL; Aderman CM; Guerin KI; Hua J; Lofqvist C; Hellstrom A; Smith LEInvest Ophthalmol Vis Sci 2010[Jun]; 51 (6): 2813-26The mouse retina has been used extensively over the past decades to study both physiologic and pathologic angiogenesis. Over time, various mouse retina models have evolved into well-characterized and robust tools for in vivo angiogenesis research. This article is a review of the angiogenic development of the mouse retina and a discussion of some of the most widely used vascular disease models. From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis.|*Disease Models, Animal[MESH]|Animals[MESH]|Mice[MESH]|Neovascularization, Physiologic/*physiology[MESH]|Retinal Neovascularization/*physiopathology[MESH]|Retinal Vessels/*physiology[MESH] |
