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lüll Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide Miller JH; Singh AJ; Northcote PTMar Drugs 2010[Mar]; 8 (4): 1059-79Marine sponges are an excellent source of bioactive secondary metabolites with potential therapeutic value in the treatment of diseases. One group of compounds of particular interest is the microtubule-stabilizing agents, the most well-known compound of this group being paclitaxel (Taxol), an anti-cancer compound isolated from the bark and leaves of the Pacific yew tree. This review focuses on two of the more recent additions to this important class of drugs, peloruside A and zampanolide, both isolated from marine sponges. Peloruside A was isolated from Mycale hentscheli collected in New Zealand coastal waters, and it already shows promising anti-cancer activity. Two other potent bioactive compounds with different modes of action but isolated from the same sponge, mycalamide A and pateamine, will also be discussed. The fourth compound, zampanolide, most recently isolated from the Tongan sponge Cacospongia mycofijiensis, has only recently been added to the microtubule-stabilizing group of compounds, and further work is in progress to determine its activity profile relative to peloruside A and other drugs of this class.|Animals[MESH]|Antineoplastic Agents/isolation & purification/pharmacology[MESH]|Bridged Bicyclo Compounds, Heterocyclic/isolation & purification/*pharmacology[MESH]|Epoxy Compounds/isolation & purification/pharmacology[MESH]|Humans[MESH]|Lactones/isolation & purification/*pharmacology[MESH]|Macrolides/isolation & purification/*pharmacology[MESH]|Microtubules/*drug effects[MESH]|Neoplasms/drug therapy/pathology[MESH]|Porifera/chemistry[MESH]|Pyrans/isolation & purification/pharmacology[MESH]|Thiazoles/isolation & purification/pharmacology[MESH] |