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lüll Unraveling mechanisms of homeostatic synaptic plasticity Pozo K; Goda YNeuron 2010[May]; 66 (3): 337-51Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of synaptic strength regulation, and in contrast to the popular view of homeostatic plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity.|Animals[MESH]|Homeostasis/*physiology[MESH]|Models, Neurological[MESH]|Nerve Net/physiology[MESH]|Neuronal Plasticity/*physiology[MESH]|Neurons/*physiology[MESH]|Synapses/*physiology[MESH]|Synaptic Transmission/physiology[MESH] |