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O-GlcNAc signaling: a metabolic link between diabetes and cancer?Slawson C; Copeland RJ; Hart GWTrends Biochem Sci 2010[Oct]; 35 (10): 547-55O-linked beta-N-acetylglucosamine (O-GlcNAc) is a sugar attachment to serine or threonine hydroxyl moieties on nuclear and cytoplasmic proteins. In many ways, O-GlcNAcylation is similar to phosphorylation because both post-translational modifications cycle rapidly in response to internal or environmental cues. O-GlcNAcylated proteins are involved in transcription, translation, cytoskeletal assembly, signal transduction, and many other cellular functions. O-GlcNAc signaling is intertwined with cellular metabolism; indeed, the donor sugar for O-GlcNAcylation (UDP-GlcNAc) is synthesized from glucose, glutamine, and UTP via the hexosamine biosynthetic pathway. Emerging research indicates that O-GlcNAc signaling and its crosstalk with phosphorylation are altered in metabolic diseases, such as diabetes and cancer.|*Signal Transduction[MESH]|Acetylglucosamine/*metabolism[MESH]|Animals[MESH]|Diabetes Mellitus/*metabolism[MESH]|Hexosamines/biosynthesis[MESH]|Humans[MESH]|Insulin/metabolism[MESH]|Neoplasms/*metabolism[MESH] |
