Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The NO cascade, eNOS location, and microvascular permeability Duran WN; Breslin JW; Sanchez FACardiovasc Res 2010[Jul]; 87 (2): 254-61The nitric oxide (NO) cascade and endothelial NO synthase (eNOS) are best known for their role in endothelium-mediated relaxation of vascular smooth muscle. Activation of eNOS by certain inflammatory stimuli and enhanced NO release have also been shown to promote increased microvascular permeability. However, it is not entirely clear why activation of eNOS by certain vasodilatory agents, like acetylcholine, does not affect microvascular permeability, whereas activation of eNOS by other inflammatory agents that increase permeability, like platelet-activating factor, does not cause vasodilation. In this review, we discuss the evidence demonstrating the role of eNOS in the elevation of microvascular permeability. We also examine the relative importance of eNOS phosphorylation and localization in its function to promote elevated microvascular permeability as well as emerging topics with regard to eNOS and microvascular permeability regulation.|*Capillary Permeability[MESH]|Animals[MESH]|Body Fluids/*metabolism[MESH]|Endothelium, Vascular/*enzymology/immunology/physiopathology[MESH]|Humans[MESH]|Inflammation Mediators/metabolism[MESH]|Inflammation/enzymology/physiopathology[MESH]|Microvessels/*enzymology/immunology/physiopathology[MESH]|Nitric Oxide Synthase Type III/*metabolism[MESH]|Nitric Oxide/*metabolism[MESH]|Phosphorylation[MESH]|Protein Transport[MESH]|Signal Transduction[MESH] |