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lüll Intermittent preventive treatment against malaria: an update Gosling RD; Cairns ME; Chico RM; Chandramohan DExpert Rev Anti Infect Ther 2010[May]; 8 (5): 589-606Intermittent preventive treatment (IPT) against malaria is a malaria control strategy aimed at reducing the burden of malaria in certain high-risk groups, namely pregnant women and children. Three strategies - IPT in pregnancy (IPTp), infants (IPTi) and children (IPTc) - are reviewed here focusing on the mechanism of action, choice of drugs available, controversies and future research. Drugs for IPT need to be co-formulated, long acting, safe and preferably administered as a single dose. There is no obvious replacement for sulfadoxine-pyrimethamine, the most commonly utilized drug combination. All strategies face similar problems of rising drug resistance, falling malaria transmission and a policy shift from controlling disease to malaria elimination and eradication. IPT is an accepted form of malaria control, but to date only IPTp has been adopted as policy.|Africa South of the Sahara[MESH]|Animals[MESH]|Antimalarials/*administration & dosage/therapeutic use[MESH]|Child[MESH]|Child, Preschool[MESH]|Clinical Trials as Topic[MESH]|Drug Administration Schedule[MESH]|Drug Combinations[MESH]|Drug Resistance[MESH]|Female[MESH]|Humans[MESH]|Infant[MESH]|Malaria[MESH]|Malaria, Falciparum/drug therapy/*prevention & control[MESH]|Parasitic Sensitivity Tests[MESH]|Plasmodium falciparum/*drug effects[MESH]|Pregnancy[MESH]|Pregnancy Complications, Parasitic/drug therapy/*prevention & control[MESH]|Pyrimethamine/administration & dosage/therapeutic use[MESH]|Sulfadoxine/administration & dosage/therapeutic use[MESH]|Treatment Outcome[MESH] |