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A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes Morishima N; Mizoguchi I; Okumura M; Chiba Y; Xu M; Shimizu M; Matsui M; Mizuguchi J; Yoshimoto TJ Biomed Biotechnol 2010[]; 2010 (ä): 605483Cytotoxic T lymphocytes (CTLs) play a critical role in the control of various cancers and infections, and therefore the molecular mechanisms of CTL generation are a critical issue in designing antitumor immunotherapy and vaccines which augment the development of functional and long-lasting memory CTLs. Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, acts on naive CD4+ T cells and plays pivotal roles as a proinflammatory cytokine to promote the early initiation of type-1 helper differentiation and also as an antiinflammatory cytokine to limit the T cell hyperactivity and production of pro-inflammatory cytokines. Recent studies revealed that IL-27 plays an important role in CD8+ T cells as well. Therefore, this article reviews current understanding of the role of IL-27 in CD8+ T cell functions and generation of CTLs.|Animals[MESH]|Humans[MESH]|Interferon-gamma/biosynthesis[MESH]|Interleukin-17/*immunology[MESH]|Neoplasms/immunology[MESH]|Organ Specificity/immunology[MESH]|Signal Transduction/immunology[MESH]|T-Lymphocytes, Cytotoxic/*cytology/*immunology[MESH] |
