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  • CD4+CD25-LAG-3+ T cells in mouse and human
  • Sumitomo S; Yamamoto K
  • Nihon Rinsho Meneki Gakkai Kaishi 2010[]; 33 (2): 92-8
  • We have recently reported a murine novel regulatory T cell population, CD4(+)CD25(-)LAG-3(+) regulatory T cells (Tregs). Microarray analysis revealed that CD4(+)CD25(-)LAG-3(+) Tregs had a unique mRNA expression profile that was different from the conventional CD4(+)CD25(+) regulatory T cells. In particular, CD4(+)CD25(-)LAG-3(+) Tregs characteristically expressed early growth response gene 2 (Egr-2) that was reported to be associated with the induction of anergy. CD4(+)CD25(-)LAG-3(+) Tregs produced high-amount of IL-10 in response to TCR stimulation and showed immunosuppressive activity in vitro and in vivo. Retroviral gene transfer of Eg-2 converted naive CD4(+) T cells into IL-10-secreting and LAG-3-expressing T cells, and Egr-2 transduced CD4(+) T cells exhibited antigen-specific immunosuppressive capacity in vivo. On the basis of these observations, we have attempted to identify a human counterpart of murine CD4(+)CD25(-)LAG-3(+) Tregs in human. CD4(+)CD25(-)LAG-3(+) T cells were found in human in similar pattern as murine CD4(+)CD25(-)LAG-3(+) Tregs. In the quantitative PCR, human CD4(+)CD25(-)LAG-3(+) T cells expressed high levels of IL-10. From the microarray analysis, we found the close similarity between human CD4(+)CD25(-)LAG-3(+) T cells and murine CD4(+)CD25(-)LAG-3(+) Tregs. Therefore, human CD4(+)CD25(-)LAG-3(+) T cells might be a human counterpart of murine CD4(+)CD25(-)LAG-3(+) Tregs.
  • |*CD4-Positive T-Lymphocytes/immunology[MESH]
  • |*T-Lymphocytes, Regulatory/immunology[MESH]
  • |Animals[MESH]
  • |Antigens, CD/metabolism[MESH]
  • |Autoimmunity/immunology[MESH]
  • |Early Growth Response Protein 2/genetics[MESH]
  • |Gene Expression[MESH]
  • |Gene Transfer Techniques[MESH]
  • |Humans[MESH]
  • |Immune Tolerance/*immunology[MESH]
  • |Interleukin-10/metabolism[MESH]
  • |Mice[MESH]
  • |Microarray Analysis[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |Receptors, Antigen, T-Cell/immunology[MESH]

  • *{{pmid20453445}}
    *<b>[ CD4+CD25-LAG-3+ T cells in mouse and human ]</b> Nihon Rinsho Meneki Gakkai Kaishi 2010; 33(2) ; 92-8 Sumitomo S; Yamamoto K


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    Nihon Rinsho Meneki Gakkai Kaishi

    92 2.33 2010