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lüll gammadelta T cell subsets: a link between TCR and function?O'Brien RL; Born WKSemin Immunol 2010[Aug]; 22 (4): 193-8The gammadelta T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because gammadelta T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that gammadelta T cell subsets also appear to be biased to carry out particular functions. This suggests that particular gammadelta TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined gammadelta T cell subsets, and evidence that their functions are predetermined in the thymus.|Animals[MESH]|Cell Differentiation[MESH]|Humans[MESH]|Receptors, Antigen, T-Cell, gamma-delta/*immunology[MESH]|Receptors, Antigen, T-Cell/immunology[MESH]|T-Lymphocyte Subsets/cytology/*immunology[MESH]|Thymus Gland/cytology/immunology[MESH] |