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Designing CD8+ T cell vaccines: it s not rocket science (yet) Yewdell JWCurr Opin Immunol 2010[Jun]; 22 (3): 402-10CD8+ T cells play important roles in clearing viral infections and eradicating tumors. Designing vaccines that elicit effective CD8+ T cell responses requires a thorough knowledge of the pathways of antigen presentation in vivo. Here, I review recent progress in understanding the activation of naive CD8+ T cells in vivo, with particular emphasis on cross-priming, the presentation of protein antigens acquired by dendritic cells from their environment. With the rapid advances in this area of research, the dawn of rational vaccine design is at hand.|*Drug Design[MESH]|Animals[MESH]|Antigen Presentation/immunology[MESH]|CD8-Positive T-Lymphocytes/*immunology[MESH]|Cross-Priming/immunology[MESH]|Humans[MESH]|Lymphocyte Activation[MESH]|Mice[MESH]|Vaccines/*immunology[MESH] |
