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lüll Clathrin assembly lymphoid myeloid leukemia-AF10-positive acute leukemias: a report of 2 cases with a review of the literature Huh JY; Chung S; Oh D; Kang MS; Eom HS; Cho EH; Han MH; Kong SYKorean J Lab Med 2010[Apr]; 30 (2): 117-21The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with the AF10 gene; these genes are present on chromosomes 11 and 10, respectively. Because the CALM-AF10 rearrangement is a rare chromosomal abnormality, it is not included in routine molecular tests for acute leukemia. Here, we describe the cases of 2 patients with the CALM-AF10 fusion gene. The first patient (case 1) was diagnosed with T-cell ALL, and the second patient (case 2) was diagnosed with AML. Both patient samples showed expression of the homeobox A gene cluster and the histone methyltransferase hDOT1L, which suggests that they mediate leukemic transformation in CALM-AF10-positive and mixed-lineage leukemia-AF10-positive leukemias. Both patients achieved complete remission after induction chemotherapy. The first patient (case 1) relapsed after double-unit cord blood transplantation; there was no evidence of relapse in the second patient (case 2) after allogenic peripheral blood stem cell transplantation. Since CALM-AF10- positive leukemias have been shown to have poor prognosis with conventional therapy, molecular tests for CALM-AF10 rearrangement would be necessary to detect minimal residual disease during follow-up.|Adolescent[MESH]|Adult[MESH]|Bone Marrow/pathology[MESH]|Chromosomes, Human, Pair 10[MESH]|Chromosomes, Human, Pair 11[MESH]|Cord Blood Stem Cell Transplantation[MESH]|Female[MESH]|Histone Methyltransferases[MESH]|Histone-Lysine N-Methyltransferase/genetics/metabolism[MESH]|Homeodomain Proteins/genetics/metabolism[MESH]|Humans[MESH]|Leukemia, Myeloid, Acute/diagnosis/*genetics/therapy[MESH]|Male[MESH]|Monomeric Clathrin Assembly Proteins/*genetics[MESH]|Oncogene Proteins, Fusion/*genetics[MESH]|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/*genetics/therapy[MESH]|Recurrence[MESH]|Transcription Factors/*genetics[MESH]|Translocation, Genetic[MESH] |