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lüll Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation Lorsch JR; Dever TEJ Biol Chem 2010[Jul]; 285 (28): 21203-7A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.|*Protein Biosynthesis[MESH]|Codon, Initiator[MESH]|Eukaryotic Initiation Factor-2/metabolism[MESH]|Eukaryotic Translation Initiation Factor 5A[MESH]|Humans[MESH]|Models, Biological[MESH]|Models, Genetic[MESH]|Mutation[MESH]|Peptide Chain Initiation, Translational[MESH]|Peptide Initiation Factors/chemistry[MESH]|Phenotype[MESH]|Protein Conformation[MESH]|Protein Structure, Tertiary[MESH]|RNA-Binding Proteins[MESH]|Ribosomes/*metabolism[MESH] |