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lüll Thrombotic microangiopathies: multimers, metalloprotease, and beyond Moake JClin Transl Sci 2009[Oct]; 2 (5): 366-73The pathophysiology of various types of thrombotic microangiopathies is coming progressively into focus. Therapeutic advances are likely to follow at a quickening pace. This discussion focuses on thrombotic thrombocytopenic purpura (TTP), the hemolytic-uremic syndrome (HUS), thrombotic microangiopathies associated with transplantation-immunosuppression or anti-angiogenesis therapy, and the preeclampsia/hemolysis-elevated liver enzymes and low platelets syndrome (HELLP).|ADAM Proteins/metabolism[MESH]|ADAMTS13 Protein[MESH]|Angiogenesis Inhibitors/pharmacology[MESH]|Antineoplastic Agents/pharmacology[MESH]|Hemolytic-Uremic Syndrome/diagnosis/genetics[MESH]|Humans[MESH]|Immunosuppressive Agents/pharmacology[MESH]|Metalloproteases/*metabolism[MESH]|Models, Biological[MESH]|Platelet Adhesiveness[MESH]|Protein Structure, Tertiary[MESH]|Purpura, Thrombotic Thrombocytopenic/diagnosis/genetics[MESH]|Thrombotic Microangiopathies/*diagnosis/*enzymology/physiopathology[MESH]|von Willebrand Factor/metabolism[MESH] |