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lüll Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo Pozsgai G; Bodkin JV; Graepel R; Bevan S; Andersson DA; Brain SDCardiovasc Res 2010[Sep]; 87 (4): 760-8AIMS: The aim of the study is to investigate transient receptor potential ankyrin 1 (TRPA1)-induced responses in the vasculature and on blood pressure and heart rate (HR), in response to TRPA1 agonists using wild-type (WT) and TRPA1 knockout (KO) mice. METHODS AND RESULTS: TRPA1 agonists allyl isothiocyanate and cinnamaldehyde (CA) significantly increased blood flow in the skin of anaesthetized WT, but not in TRPA1 KO mice. CA also induced TRPA1-dependent relaxation of mesenteric arteries. Intravenously injected CA induced a transient hypotensive response accompanied by decreased HR that was, depending on genotype and dose, followed by a more sustained dose-dependent pressor response (10-320 micromol/kg). CA (80 micromol/kg) induced a depressor response that was significantly less in TRPA1 KO mice, with minimal pressor effects. The pressor response of a higher CA dose (320 micromol/kg) was observed in WT but not in TRPA1 KO mice, indicating involvement of TRPA1. Experiments using TRP vanilloid 1 (TRPV1) KO and calcitonin gene-related peptide (CGRP) KO mice provided little evidence for the involvement of TRPV1 or CGRP, nor did blocking substance P receptors affect responses. However, the cholinergic antagonist atropine sulphate (5 mg/kg) significantly inhibited the depressor response and slowed HR with CA (80 micromol/kg), but had no effect on pressor responses. The pressor response remained unaffected, even in the presence of the ganglion blocker hexamethonium bromide (1 mg/kg). The alpha-adrenergic blocker prazosin hydrochloride (1 mg/kg) significantly inhibited both components, but not slowed HR. CONCLUSION: TRPA1 is involved in mediating vasodilation. TRPA1 can also influence changes in blood pressure of possible relevance to autonomic system reflexes and potentially to vasovagal/neurocardiogenic syncope disorders.|*Hemodynamics/drug effects[MESH]|*Microcirculation/drug effects[MESH]|Acrolein/analogs & derivatives/pharmacology[MESH]|Adrenergic alpha-1 Receptor Antagonists/pharmacology[MESH]|Animals[MESH]|Atropine/pharmacology[MESH]|Blood Pressure[MESH]|Calcitonin Gene-Related Peptide/genetics/metabolism[MESH]|Dose-Response Relationship, Drug[MESH]|Female[MESH]|Ganglionic Blockers/pharmacology[MESH]|Heart Rate[MESH]|Hexamethonium/pharmacology[MESH]|Isothiocyanates/pharmacology[MESH]|Male[MESH]|Mesenteric Arteries/drug effects/*metabolism[MESH]|Mice[MESH]|Mice, Inbred C57BL[MESH]|Mice, Knockout[MESH]|Muscarinic Antagonists/pharmacology[MESH]|Prazosin/pharmacology[MESH]|Regional Blood Flow[MESH]|Skin/*blood supply[MESH]|Substance P/metabolism[MESH]|TRPA1 Cation Channel[MESH]|Time Factors[MESH]|Transient Receptor Potential Channels/agonists/deficiency/genetics/*metabolism[MESH]|Vasodilation[MESH] |