Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Cancer-selective apoptotic effects of extracellular and intracellular Par-4 Shrestha-Bhattarai T; Rangnekar VMOncogene 2010[Jul]; 29 (27): 3873-80Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.|*Apoptosis[MESH]|Animals[MESH]|Apoptosis Regulatory Proteins/chemistry/*metabolism[MESH]|Endoplasmic Reticulum Chaperone BiP[MESH]|Extracellular Space/*metabolism[MESH]|Humans[MESH]|Intracellular Space/*metabolism[MESH]|Neoplasms/*metabolism/*pathology[MESH]|Tumor Suppressor Proteins/chemistry/metabolism[MESH] |