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lüll The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer Greene SB; Herschkowitz JI; Rosen JMRNA Biol 2010[May]; 7 (3): 300-4Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.|Animals[MESH]|Breast Neoplasms/*genetics/metabolism/pathology[MESH]|Carcinoma/*genetics/metabolism/pathology[MESH]|Female[MESH]|Gene Expression Regulation, Developmental[MESH]|Humans[MESH]|Mammary Glands, Human/*embryology/growth & development/metabolism[MESH]|Mice[MESH]|MicroRNAs/*genetics/metabolism/*physiology[MESH]|Models, Biological[MESH]|Organogenesis/genetics[MESH] |