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lüll CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation Cho S; Schroeder S; Ott MCell Cycle 2010[May]; 9 (9): 1697-705The cyclin T/CDK9 complex, also called positive transcription elongation factor b (P-TEFb) phosphorylates the C-terminal domain of the large fragment of the RNA polymerase II. This action is a hallmark of the transition from transcription initiation to elongation. P-TEFb is itself modified by phosphorylation and ubiquitination. Recently, the core components of P-TEFb, cyclin T1 and CDK9, were identified as novel substrates of histone acetyltransferases. Here, we review how posttranslational modifications regulate the activity of the P-TEFb complex and discuss how acetylation of the complex optimizes transcription elongation in the context of other posttranslational modifications.|*Protein Processing, Post-Translational[MESH]|Cyclin T/metabolism[MESH]|Cyclin-Dependent Kinase 9/metabolism[MESH]|Histone Acetyltransferases/metabolism[MESH]|Positive Transcriptional Elongation Factor B/*metabolism[MESH]|RNA Polymerase II/metabolism[MESH]|Transcription Factors/metabolism[MESH]|Transcription, Genetic[MESH] |