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  • CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation
  • Cho S; Schroeder S; Ott M
  • Cell Cycle 2010[May]; 9 (9): 1697-705
  • The cyclin T/CDK9 complex, also called positive transcription elongation factor b (P-TEFb) phosphorylates the C-terminal domain of the large fragment of the RNA polymerase II. This action is a hallmark of the transition from transcription initiation to elongation. P-TEFb is itself modified by phosphorylation and ubiquitination. Recently, the core components of P-TEFb, cyclin T1 and CDK9, were identified as novel substrates of histone acetyltransferases. Here, we review how posttranslational modifications regulate the activity of the P-TEFb complex and discuss how acetylation of the complex optimizes transcription elongation in the context of other posttranslational modifications.
  • |*Protein Processing, Post-Translational[MESH]
  • |Cyclin T/metabolism[MESH]
  • |Cyclin-Dependent Kinase 9/metabolism[MESH]
  • |Histone Acetyltransferases/metabolism[MESH]
  • |Positive Transcriptional Elongation Factor B/*metabolism[MESH]
  • |RNA Polymerase II/metabolism[MESH]
  • |Transcription Factors/metabolism[MESH]
  • |Transcription, Genetic[MESH]





  • *{{pmid20436276}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=20436276 CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation ]</b> Cell Cycle 2010; 9(9) ; 1697-705 Cho S; Schroeder S; Ott M

        *20436276*

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    Cell Cycle

    1697 9.9 2010