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lüll Emerging roles of PDGF-D signaling pathway in tumor development and progression Wang Z; Ahmad A; Li Y; Kong D; Azmi AS; Banerjee S; Sarkar FHBiochim Biophys Acta 2010[Aug]; 1806 (1): 122-30Platelet-derived growth factor-D (PDGF-D) can regulate many cellular processes, including cell proliferation, apoptosis, transformation, migration, invasion, angiogenesis and metastasis. Therefore PDGF-D signaling has been considered to be important in human malignancies, and thus PDGF-D signaling may represent a novel therapeutic target, and as such suggests that the development of agents that will target PDGF-D signaling is likely to have a significant therapeutic impact on human cancers. This mini-review describes the mechanisms of signal transduction associated with PDGF-D signaling to support the role of PDGF-D in the carcinogenesis. Moreover, we summarize data on several PDGF-D inhibitors especially naturally occurring "chemopreventive agent" such an indole compound, which we believe could serve as a novel agent for the prevention of tumor progression and/or treatment of human malignancies by targeted inactivation of PDGF-D signaling.|Animals[MESH]|Cell Proliferation[MESH]|Cell Survival[MESH]|Disease Progression[MESH]|Epithelial Cells/pathology[MESH]|Humans[MESH]|Interleukin-1beta/physiology[MESH]|Lymphokines/*physiology[MESH]|Mesoderm/pathology[MESH]|MicroRNAs/physiology[MESH]|Neoplasms/*etiology/pathology[MESH]|Platelet-Derived Growth Factor/*physiology[MESH]|Reactive Oxygen Species/metabolism[MESH]|Signal Transduction/*physiology[MESH]|Urokinase-Type Plasminogen Activator/physiology[MESH] |