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lüll Ligand recognition during thymic development and gammadelta T cell function specification Meyer C; Zeng X; Chien YHSemin Immunol 2010[Aug]; 22 (4): 207-13gammadelta T cells develop in the thymus before entering the periphery. Recent work suggests that thymic development does little to constrain gammadelta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-naive gammadelta T cells produce IL-17, ligand-experienced cells make IFN-gamma and those that are strongly self-reactive make IL-4. Importantly, gammadelta T cells are able to make cytokines immediately upon TCR engagement. These characteristics allow gammadelta T cells to initiate an acute inflammatory response to pathogens and to host antigens revealed by injury. These advances warrant a fresh look at how gammadelta T cells may function in the immune system.|Animals[MESH]|Cell Differentiation[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Ligands[MESH]|Receptors, Antigen, T-Cell, gamma-delta/*immunology/metabolism[MESH]|Signal Transduction[MESH]|Thymus Gland/cytology/*immunology/metabolism[MESH] |