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When to start antiretroviral therapy Jain V; Deeks SGCurr HIV/AIDS Rep 2010[May]; 7 (2): 60-8The question of when to start combination antiretroviral therapy for treatment-naive patients has always been controversial. This is particularly true in the current era, with major guidelines recommending very different treatment strategies. Despite a lack of clarity regarding the optimal time to begin therapy, there has been a recent shift toward earlier initiation. This more aggressive approach is driven by several observations. First, effective viral suppression with therapy can prevent non-AIDS-related morbidity and mortality. Second, therapy can prevent irreversible harm to the human immune system. Third, therapy may prevent transmission of HIV to others, and thus have a potential public health benefit. For patients who are motivated and willing to initiate early treatment, the collective benefits of early therapy may outweigh the well-documented risks of antiretroviral medications.|AIDS-Related Opportunistic Infections/mortality/prevention & control[MESH]|Acquired Immunodeficiency Syndrome/mortality/prevention & control[MESH]|Anti-HIV Agents/administration & dosage/adverse effects/*therapeutic use[MESH]|CD4 Lymphocyte Count[MESH]|Drug Administration Schedule[MESH]|HIV Infections/*drug therapy/mortality[MESH]|Humans[MESH]|Practice Guidelines as Topic[MESH]|Randomized Controlled Trials as Topic[MESH] |
