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lüll Relaxin: review of biology and potential role in treating heart failure Teichman SL; Unemori E; Teerlink JR; Cotter G; Metra MCurr Heart Fail Rep 2010[Jun]; 7 (2): 75-82Relaxin is a naturally occurring human peptide initially identified as a reproductive hormone. More recently, relaxin has been shown to play a key role in the maternal hemodynamic and renal adjustments that accommodate pregnancy. An understanding of these physiologic effects has led to the evaluation of relaxin as a pharmacologic agent for the treatment of patients with acute heart failure. Preliminary results have been encouraging. In addition, the other known biologic properties of relaxin, including anti-inflammatory effects, extracellular matrix remodeling effects, and angiogenic and anti-ischemic effects, all may play a role in potential benefits of relaxin therapy. Ongoing, large-scale clinical testing will provide additional insights into the potential role of relaxin in the treatment of heart failure.|Female[MESH]|Heart Failure/*drug therapy[MESH]|Hemodynamics/*drug effects[MESH]|Humans[MESH]|Pregnancy[MESH]|Relaxin/*pharmacology/*therapeutic use[MESH]|Vasodilation/*drug effects[MESH] |