Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
MicroRNAs, macrocontrol: regulation of miRNA processing Slezak-Prochazka I; Durmus S; Kroesen BJ; van den Berg ARNA 2010[Jun]; 16 (6): 1087-95MicroRNAs (miRNAs) are a set of small, non-protein-coding RNAs that regulate gene expression at the post-transcriptional level. Maturation of miRNAs comprises several regulated steps resulting in approximately 22-nucleotide single-stranded mature miRNAs. Regulation of miRNA expression can occur both at the transcriptional level and at the post-transcriptional level during miRNA processing. Recent studies have elucidated specific aspects of the well-regulated nature of miRNA processing involving various regulatory proteins, editing of miRNA transcripts, and cellular location. In addition, single nucleotide polymorphisms in miRNA genes can also affect the processing efficiency of primary miRNA transcripts. In this review we present an overview of the currently known regulatory pathways of miRNA processing and provide a basis to understand how aberrant miRNA processing may arise and may be involved in pathophysiological conditions such as cancer.|*Gene Expression Regulation[MESH]|*RNA Processing, Post-Transcriptional[MESH]|Animals[MESH]|Base Sequence[MESH]|Caenorhabditis elegans Proteins/genetics/metabolism[MESH]|Caenorhabditis elegans/genetics[MESH]|DNA/chemistry/genetics[MESH]|MicroRNAs/chemistry/*genetics[MESH]|Mutation[MESH]|Protein Biosynthesis[MESH]|Proteins/genetics[MESH]|Ribonuclease III/genetics/metabolism[MESH]|Transcription, Genetic[MESH] |
