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lüll Hereditary and familial colon cancer Jasperson KW; Tuohy TM; Neklason DW; Burt RWGastroenterology 2010[Jun]; 138 (6): 2044-58Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer. In addition to the syndromes, up to one-third of colon cancers exhibit increased familial risk, likely related to inheritance. A number of less penetrant, but possibly more frequent susceptibility genes have been identified for this level of inheritance. Clarification of predisposing genes allows for accurate risk assessment and more precise screening approaches. This review examines the colon cancer syndromes, their genetics and management, and also the common familial colon cancers with current genetic advances and screening guidelines.|*Gene Expression Regulation, Neoplastic[MESH]|Adenomatous Polyposis Coli/genetics[MESH]|Animals[MESH]|Colonic Neoplasms/diagnosis/*genetics/prevention & control/therapy[MESH]|Colonoscopy[MESH]|Colorectal Neoplasms, Hereditary Nonpolyposis/genetics[MESH]|Genetic Predisposition to Disease[MESH]|Genetic Testing[MESH]|Heredity[MESH]|Humans[MESH]|Mass Screening/methods[MESH]|Pedigree[MESH]|Peutz-Jeghers Syndrome/genetics[MESH]|Phenotype[MESH]|Predictive Value of Tests[MESH]|Risk Assessment[MESH]|Risk Factors[MESH] |