Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Dynamic strength of titin s Z-disk end Kollar V; Szatmari D; Grama L; Kellermayer MSJ Biomed Biotechnol 2010[]; 2010 (�): 838530Titin is a giant filamentous protein traversing the half sarcomere of striated muscle with putative functions as diverse as providing structural template, generating elastic response, and sensing and relaying mechanical information. The Z-disk region of titin, which corresponds to the N-terminal end of the molecule, has been thought to be a hot spot for mechanosensing while also serving as anchorage for its sarcomeric attachment. Understanding the mechanics of titin's Z-disk region, particularly under the effect of binding proteins, is of great interest. Here we briefly review recent findings on the structure, molecular associations, and mechanics of titin's Z-disk region. In addition, we report experimental results on the dynamic strength of titin's Z1Z2 domains measured by nanomechanical manipulation of the chemical dimer of a recombinant protein fragment.|Biomechanical Phenomena[MESH]|Connectin[MESH]|Elasticity[MESH]|Escherichia coli/genetics[MESH]|Humans[MESH]|Monte Carlo Method[MESH]|Muscle Proteins/*chemistry/genetics/metabolism[MESH]|Protein Folding[MESH]|Protein Kinases/*chemistry/genetics/metabolism[MESH]|Protein Stability[MESH]|Protein Structure, Tertiary[MESH]|Recombinant Proteins/chemistry/genetics/metabolism[MESH]|Shear Strength[MESH] |