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lüll Importance of IL-18-induced super Th1 cells for the development of allergic inflammation Nakanishi K; Tsutsui H; Yoshimoto TAllergol Int 2010[Jun]; 59 (2): 137-41Th1 cells, which express IL-18R, produce IFN-gamma in response to Ag and IL-2 and increase further production of IFN-gamma upon additional IL-18 stimulation. They simultaneously produce Th2 cytokines (IL-9 and IL-13), GM-CSF and chemokines (RANTES, MIP-1alpha). Human Th1 cells also produce IFN-gamma and IL-13 in response to anti-CD3 and IL-18. Recently, we demonstrated Th1 cells induce intrinsic type atopic asthma and dermatitis by production of Th1- and Th2-cytokines and chemokines. Here, we review the pathological roles of Th1 cells, stimulated with Ag and IL-18 in vivo, in the pathogenesis of allergic disorders by production of Th1 and Th2 cytokines and chemokines. Based on this unique function of Ag- plus IL-18-stimulated Th1 cells, we proposed to designate them as "super Th1 cells".|Allergens/immunology[MESH]|Animals[MESH]|Anti-Allergic Agents/pharmacology/therapeutic use[MESH]|Asthma/complications/drug therapy/genetics/*immunology[MESH]|Genetic Association Studies[MESH]|Humans[MESH]|Infections/complications/drug therapy/genetics/*immunology[MESH]|Inflammation[MESH]|Interleukin-18/genetics/*immunology[MESH]|Lymphocyte Activation/genetics[MESH]|Models, Immunological[MESH]|Polymorphism, Genetic[MESH]|Receptors, Interleukin-18/antagonists & inhibitors/*immunology[MESH]|Th1 Cells/*immunology[MESH] |