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lüll IL-1 and Allergy Nambu A; Nakae SAllergol Int 2010[Jun]; 59 (2): 125-35IL-1 is a well-characterized proinflammatory cytokine that is involved in host defense and autoimmune diseases. IL-1 can promote activation of T cells, including Th1 cells, Th2 cells and Th17 cells, and B cells, suggesting that IL-1 may contribute to the development of various types of T-cell-mediated diseases. This report reviews and discusses the role of IL-1 in the pathogenesis of allergic diseases based on studies using IL-1-related gene-deficient mice.|Animals[MESH]|Anti-Allergic Agents/pharmacology/therapeutic use[MESH]|Humans[MESH]|Hypersensitivity/drug therapy/genetics/*immunology[MESH]|Interleukin-1/genetics/*immunology[MESH]|Lymphocyte Activation/genetics[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Receptors, Interleukin-1/antagonists & inhibitors[MESH]|T-Lymphocytes/*immunology[MESH] |