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lüll The TRPV4 channel contributes to intercellular junction formation in keratinocytes Sokabe T; Fukumi-Tominaga T; Yonemura S; Mizuno A; Tominaga MJ Biol Chem 2010[Jun]; 285 (24): 18749-58Transient receptor potential vanilloid 4 (TRPV4) channel is a physiological sensor for hypo-osmolarity, mechanical deformation, and warm temperature. The channel activation leads to various cellular effects involving Ca(2+) dynamics. We found that TRPV4 interacts with beta-catenin, a crucial component linking adherens junctions and the actin cytoskeleton, thereby enhancing cell-cell junction development and formation of the tight barrier between skin keratinocytes. TRPV4-deficient mice displayed impairment of the intercellular junction-dependent barrier function in the skin. In TRPV4-deficient keratinocytes, extracellular Ca(2+)-induced actin rearrangement and stratification were delayed following significant reduction in cytosolic Ca(2+) increase and small GTPase Rho activation. TRPV4 protein located where the cell-cell junctions are formed, and the channel deficiency caused abnormal cell-cell junction structures, resulting in higher intercellular permeability in vitro. Our results suggest a novel role for TRPV4 in the development and maturation of cell-cell junctions in epithelia of the skin.|Actins/chemistry/metabolism[MESH]|Animals[MESH]|COS Cells[MESH]|Calcium/chemistry/metabolism[MESH]|Cell Communication[MESH]|Chlorocebus aethiops[MESH]|Cytoskeleton/metabolism[MESH]|Female[MESH]|Intercellular Junctions/*metabolism[MESH]|Keratinocytes/cytology/*metabolism[MESH]|Male[MESH]|Mice[MESH]|Models, Biological[MESH]|Osmolar Concentration[MESH]|TRPV Cation Channels/*metabolism[MESH]|Temperature[MESH]|beta Catenin/metabolism[MESH] |