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lüll Cohesinopathies, gene expression, and chromatin organization Bose T; Gerton JLJ Cell Biol 2010[Apr]; 189 (2): 201-10The cohesin protein complex is best known for its role in sister chromatid cohesion, which is crucial for accurate chromosome segregation. Mutations in cohesin proteins or their regulators have been associated with human diseases (termed cohesinopathies). The developmental defects observed in these diseases indicate a role for cohesin in gene regulation distinct from its role in chromosome segregation. In mammalian cells, cohesin stably interacts with specific chromosomal sites and colocalizes with CTCF, a protein that promotes long-range DNA interactions, implying a role for cohesin in genome organization. Moreover, cohesin defects compromise the subnuclear position of chromatin. Therefore, defects in the cohesin network that alter gene expression and genome organization may underlie cohesinopathies.|*Gene Expression Regulation[MESH]|Animals[MESH]|Cell Cycle Proteins/chemistry/genetics/*metabolism[MESH]|Cell Cycle/physiology[MESH]|Chromatin/chemistry/*metabolism[MESH]|Chromosomal Proteins, Non-Histone/chemistry/genetics/*metabolism[MESH]|Chromosome Segregation[MESH]|Cohesins[MESH]|DNA/genetics/metabolism[MESH]|Humans[MESH]|Models, Molecular[MESH]|Multiprotein Complexes[MESH]|Mutation[MESH] |