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Clinical status of duplex RNA Watts JK; Corey DRBioorg Med Chem Lett 2010[Jun]; 20 (11): 3203-7Double-stranded RNA has become a ubiquitous tool for inhibition of gene expression in the laboratory. If similar success could be achieved in vivo, duplex RNA might provide a new class of therapeutics capable of treating a broad spectrum of disease. Chemists and biologists developing duplex RNA as a drug have made progress but continue to face challenges. This review presents the current status of duplex RNA in the clinic and comments on future prospects for the approach.|Animals[MESH]|Humans[MESH]|Mice[MESH]|Nanoparticles[MESH]|RNA, Double-Stranded/*chemistry/pharmacology[MESH]|RNA, Small Interfering[MESH]|Vascular Endothelial Growth Factor A/genetics[MESH] |
