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New role for Agrin in T cells and its potential importance in immune system regulation Jury EC; Kabouridis PSArthritis Res Ther 2010[]; 12 (2): 205Agrin plays a crucial role in the maintenance of the neuromuscular junction. However, it is expressed in other tissues as well, including T lymphocytes, where cell activation induces its expression. Agrin from activated T cells has the capacity to induce aggregation of key receptors and to regulate signalling. Interestingly, T cells isolated from patients with systemic lupus erythematosus over-express Agrin and its co-stimulation with the T cell receptor enhances production of pathogenic cytokines. These early studies point to an important function for Agrin in T cell biology and make the case for a more thorough and systematic investigation into its role in the immune system.|Agrin/*physiology[MESH]|Antigen-Presenting Cells/*immunology[MESH]|Humans[MESH]|Immune System/*physiology[MESH]|Immunological Synapses/*immunology[MESH]|Lymphocyte Activation/immunology[MESH]|Signal Transduction[MESH]|T-Lymphocytes/*immunology[MESH] |
